Web3 Oct 2014 · In prostate epithelial cells, overexpression of mutant SPOP resulted in increased total SPOP and DEK protein expression, as expected. However, both SPOP … WebThe metabolomics data of LNCaP CON, SPOP_WT, SPOP_Y87N, and SPOP_F133L cells were evaluated by partial least squares-discriminant analysis (PLS-DA). Four groups could be clearly differentiated with an explanation ability of R 2 X=0.512, R 2 Y=0.616 and predictive ability of Q 2 =0.475. Totally, 36 differential metabolites were defined with ...
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WebSPOPS119N SPOPF125V SPOPW131G SPOPF133L SPOPF133V Fig. 1. PC-associated SPOP mutants lack the capacity of SPOPWT to interact with SRC-3. (A) Distribution on the SPOP gene of the most common muta-tions found in PC. These recurrent mutations are clustered to the N-terminal MATH domain, which is necessary for SPOP binding to substrates … Web14 Jun 2016 · Experiments using haemagglutinin-tagged TRIM24 indicated that this protein decayed more rapidly in the presence of wild-type (wt)SPOP than the SPOP-F133L … green recycle symbol meaning
Prostate cancer-associated mutations in speckle-type POZ protein (SPOP …
Web1 Jul 2024 · We identified ITCH as a candidate protein for SPOP-mediated degradation via mass spectrometry. We demonstrated the interaction between SPOP and ITCH, and found that the SPOP F133L mutation... Web11 Dec 2024 · When you purchase through links on our site, we may earn a teeny-tiny 🤏 affiliate commission.ByHonest GolfersUpdated onDecember 11, 2024Too much spin on … fly us flag in rain