WebJul 29, 2024 · It has been suggested that for every 10 cases of alanine aminotransferase (ALT) elevation (>10 times the upper limit of normal) in a clinical trial, there will be one … WebApr 14, 2024 · We emphasize the importance of close monitoring of liver enzymes and evaluation of liver computed tomographic imaging as well as liver biopsy during treatment with amiodarone, and discontinuation should be considered when amiodarone-induced hepatotoxicity is suspected. ... which inhibits removal of lysosomal lipids and leads to …
Drug-induced fatty liver disease: An overview of pathogenesis and ...
WebJun 15, 2008 · Abstract. We have constructed a large-scale transcriptome database of rat liver treated with various drugs. In an effort to identify a biomarker for diagnosis of hepatic phospholipidosis, we extracted 78 probe sets of rat hepatic genes from data of 5 drugs, amiodarone, amitriptyline, clomipramine, imipramine, and ketoconazole, which actually … WebJan 16, 2015 · Amiodarone-induced cirrhosis (AIC) is a rare and challenging diagnosis, and established mortality rates for AIC can be as high as 60% at 5 months. 1 The most common reported symptoms of AIC are generalized weakness, abdominal pain, and distention, with nearly one-quarter of patients presenting with some degree of abdominal distention or … simplicity\\u0027s lx
Phospholipidosis - Wikipedia
WebJul 29, 2024 · It has been suggested that for every 10 cases of alanine aminotransferase (ALT) elevation (>10 times the upper limit of normal) in a clinical trial, there will be one case of more severe liver injury that develops once the drug is widely available [ 30,31 ]. WebApr 6, 2024 · They serve as a repository of various lipids and are associated with many cellular metabolic processes, including energy storage, membrane synthesis, and protein homeostasis. LDs are prominent in a variety of diseases related to lipid regulation, including obesity, fatty liver disease, diabetes, and atherosclerosis. WebApr 23, 2024 · Drug-induced phospholipidosis (PL) is a storage disorder caused by the formation of phospholipid-drug complexes in lysosomes. Because of the diversity of PL between species, human cell-based assays have been … simplicity\u0027s ls