WebJan 1, 2024 · The approval number is IACUC-2024001. The Ythdc1 flox/flox mice were provided by the Cambridge-suda Genomic Resource Center. The exons 5–7 of the Ythdc1 gene were flanked by two loxp sites. Ythdc1 flox/flox mice were crossed with ... YTHDC1 (77422S, CST, 1:2000 dilution); β-actin (60008-1-lg, Proteintech, 1:5000 dilution) and … WebMay 21, 2024 · YTHDC1 well co-localized with GW-body maker GW182, however, no colocalization was identified between YTHDC1 and P-body marker DCP1A (Fig. 7k), which further reveals the role of YTHDC1 in target ...
YTHDC1 - Wikipedia
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YTHDC1 (D10) Antibody Cell Signaling Technology
WebDec 4, 2024 · YTHDC1 also mediates nuclear export and splicing of N 6-methyladenosine methylated mRNAs [44, 45]. We revealed that METTL3 or METTL14 only regulates the mRNA expression of VPS25. Furthermore, YTHDC1 only regulates VPS25 protein expression. We also demonstrated that YTHDC1 affects the proliferation of glioma cells … WebDec 30, 2024 · YTHDC1 is localized to cell cycle-associated YT bodies, commonly known as nuclear speckles, and is primarily responsible for facilitating the cytoplasmic export of m 6 A-marked mRNA. Although YTHDC1 has been shown to preferentially bind noncoding RNAs such as XIST, 9 there are many mRNAs that are exported from the nucleus without … WebMay 25, 2024 · The N 6-methyladenosine (m 6 A) modification is the most prevalent internal RNA modification in eukaryotes. The majority of m 6 A sites are found in the last exon and 3’ UTRs. Here we show that the … cyclopithecus