Circpvt1 review
WebJan 28, 2024 · Here, we review circPVT1 origin and biogenesis highlighting the most important mechanisms through which it plays a fundamental role in oncogenesis, such … WebMay 27, 2024 · Oral squamous cell carcinoma (OSCC) is a common malignant tumor occurring in the oral cavity. Circular RNAs (circRNAs) play a crucial regulatory role in many cancers. This study aimed to investigate the function of circRNA plasmacytoma variant translocation 1 (PVT1) (circPVT1) in OSCC and its potential mechanism. The levels of …
Circpvt1 review
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WebCircPVT1 as potential clinical biomarker. Although studies on circPVT1 in malignancy remained scanty, significant association of the candidate with disease onset and outcome indicated it as a promising biomarker of … WebJun 29, 2024 · CircPVT1 derived from PVT1 gene is also a critical non-coding oncogenic RNA. ... (miRNAs), and/or proteins, thereby regulating a variety of cellular processes. This review summarizes the characteristics of PVT1, including their biological functions and the related mechanisms, which was the most comprehensive to date.
WebCircular PVT1: an oncogenic non-coding RNA with emerging clinical ... WebResults: CircPVT1 and TRIM23 levels were elevated, while miR-377 was decreased in HCC. CircPVT1 knockdown restrained proliferation and glycolysis, but enhanced apoptosis in HCC cells. CircPVT1 could bind to miR-377 and inhibition of miR-377 restored circPVT1 knockdown-mediated effect on HCC cells.
WebThis review summarizes various pathways through which PVT1 regulates the progression of cancer via miRNAs. We also propose additional regulatory mechanisms of PVT1 and their potential clinical applications. ... The circular PVT1 (circPVT1) locus is contained within the lncPVT1, which originates from the exon 2 of the PVT1 gene. Several studies ... WebMay 7, 2024 · Background Medullary thyroid cancer (MTC) represents 13.4 % of all thyroid cancers-related deaths. The treatments for MTC are very limited especially for patients with distal metastasis. Therefore, it is critical to understand the mechanisms of MTC to pursue novel therapeutic avenues. Here, we studied the function of circPVT1/miR-455-5p in …
WebCircPVT1 has been found to increase proliferation of gastric cancer cell through serving as a molecular sponge for miR-125 family members . Moreover, expression of circPVT1 …
WebMar 18, 2024 · For instance, the down-regulation of CircPVT1 represses the growth of liver cancer cell via modulating miR-3666/SIRT7 axis. 11 Additionally, circPVT1 functions as a ceRNA of miR-526b, thus promoting the metastasis of osteosarcoma via up-regulation FOXC2. 12 Kun-Peng Z et al also found that circPVT1 enhances the chemoresistance of … how to subtract fractions with piWebJun 10, 2024 · CircPVT1 promotes LUSC progression via HuR/circPVT1/miR-30d and miR-30e/CCNF cascade. Also, it acts as a novel diagnostic biomarker or treatment target of individuals diagnosed with LUSC. Background Lung cancer (LC) accounts for the highest rate of cancer incidence and mortalities across the globe. reading month ideas for elementary schoolWebMar 1, 2024 · The expression of circPVT1 is often upregulated in GC tissues due to the amplification of its genomic locus. circPVT1 may promote cell proliferation by acting as a sponge for members of the miR-125 family. The level of circPVT1 was observed as an independent prognostic marker for overall survival and disease-free survival of patients … how to subtract fractions with a whole numberWebApr 3, 2024 · CircPVT1 acts as a competing endogenous RNA (ceRNA) to sponge miR-181a-2-3p, promoting the expression of ESR1 and downstream ERα-target genes and … how to subtract fractions with same numeratorWebSeveral theories on the origin of adenomyosis (ADS) have been proposed, of which the most widely accepted is the fundamental pathogenic role of uterine eutopic endometrium. Emerging evidence suggests that circular RNAs participate in the multiple how to subtract hundredsWebOct 15, 2024 · b The circPVT1 was markedly up-regulated in EC tissues compared with the adjacent tissues. **P < 0.01; n = 20. c The level of circPVT1 was significantly increased in cancer cell lines, especially in EC109, TE-1 and TE-10. **P < 0.01; n = 3. d The circPVT1 levels decreased significantly when TE-1 cells were maintained to over-confluence. how to subtract hours from datetimeWebFeb 16, 2024 · CircPVT1 was over-expressed in OS tissues and cells, and correlated with clinical features of OS. Over-expressed circPVT1 reduced the survival of OS patients. CircPVT1 was up-regulated in chemoresistant OS cells compared to their parental cells. CircPVT1 inhibition suppressed the proliferation and chemoresistance of OS cells. how to subtract fractions and mixed numbers